ABSTRACT
Introduction: Matched unrelated donors (MUD) for hematopoietic progenitor cell (HPC) transplantation are facilitated through the National Marrow Donor Program. Most peripheral blood collections (HPC-A) are obtained in a single day apheresis collection. Extensive planning is required to coordinate the mobilization, collection, and shipment of the product with the conditioning and infusing at the transplant center. Typically, these products are infused fresh, although the COVID pandemic has necessitated cryopreservation in many instances. It was perceived that the number of two-day MUD collections was increasing at our institution. This study was performed to determine if this was true and to evaluate potential causes. Method(s): The project was considered a laboratory quality improvement project;IRB approval was not required per institutional guideline. Data was collected retrospectively for 120 HPC(A) MUD from August 2017-November 2020 including donor's age, weight, and sex, along with recipient to donor weight ratio. Each factor was analyzed against CD34 yield per day of collection. Result(s): Of the 120 donors, 5.6% collected over 2 days in 2017(n=1), 3.7 % (n=1, 2018), 3.6 % (n=1, 2019) with highest observation 17% (n=8) in 2020 (Image). Donor age, donor weight, donor sex, and recipient to donor weight ratio were compared to absolute CD34 yield. There was not a correlation seen between CD34 yield and donor age nor weight. However, donor sex along with recipient/donor weight ratio each showed a correlation in the number of collections required. Of those requiring a second day of collection, 73% were female while 27% were male. Two-day collections could be predicted with 83% accuracy in female with >1.09 recipient/donor weight ratio and male with > 1.49 recipient/donor weight ratio.(Figure Presented) Conclusion(s): The observed trend of increased 2-day NMDP collections coincided with an increase in frequency of female donors. Not surprisingly, higher recipient/donor weight was associated with a higher likelihood of 2-day collections. The size and scope of this study do not allow us to determine a definitive cause. However, it was noted these findings coincided with new donor selection guidelines prioritizing HLA-DP match potentially leading to an increase in female donors being selected. Unexpected two-day collection can have significant effects on transplantation. Developing a predictive algorithm with 83% accuracy allows for patient and staff preparation to anticipate the likelihood for additional collections. Having the product collected and received in advance, prior to patient conditioning improves logistics and removes some variability from scheduling. Larger, multicenter studies are required to determine if increased numbers of two-day collection of MUD are occurring at other centers and to the potential causesCopyright © 2023 American Society for Transplantation and Cellular Therapy
ABSTRACT
Introduction: The pandemic COVID-19 has profoundly disrupted the social and economic activities that lead to the trend of work from home. The aim of this study was to determine the prevalence of depression, anxiety, and stress and their associations with quality of life among parents who work from home during the COVID-19 pandemic in Shah Alam. Methods: A total of 384 parents were included in this cross-sectional study through convenience and snowball sampling techniques. An online survey methodology, Google Form, involving Depression, Anxiety, and Stress Screening 21 Item Questionnaire and Short Form 36 Health Survey Questionnaire were utilized to collect the data via WhatsApp, Facebook, and Telegram. Descriptive analysis, binary logistic regression, and Spearman’s correlation coefficient were used to analyse the recorded data using SPSS version 26. Results: Majority of participants were 40 - 49 years old, female, Malay, married and have three numbers of children. It was found that about 58.3%, 59.1%, and 38.8% of the participants were having depressed, anxious, and stressed, respectively. However, the findings indicated lower mean scores among participants in all SF-36 domains except vitality when compared with the Malaysian norm. Marital status was associated with depression and gender was associated with anxiety. No sociodemographic variable was associated with stress. All domains of SF-36 were negatively associated with depression, anxiety, and stress. Conclusion: Higher level of depression, anxiety, and stress reduced the quality of life. Hence, effective interventions for better psychological status and quality of life of parents during a potential subsequent pandemic is necessary. © 2022 UPM Press. All rights reserved.
ABSTRACT
Introduction: Environmental Health Officers (EHO) and Assistant Environmental Health Officers (AEHO), are among the front liners involved in combating COVID-19 pandemic in Malaysia. The overburdening strain, prolonged working hours, and inability to take time off have had an indirect psychological impact on them, resulting in a quality-of-life imbalance. Hence, the aim of this study was to investigate the likelihood and associated factors contributing to depression, anxiety, stress, and Quality of Life (QoL) of EHO and AEHO in Selangor during the COVID-19 pandemic. Methods: A cross-sectional study involving 170 participants was conducted in Selangor through the distribution of an online survey. The survey comprised of sociodemographic data, Depression, Anxiety and Stress Screening 21 Item Questionnaire (DASS-21) and Short Form 36 Health Survey Questionnaire (SF-36). Results: Approximately, 54.7%, 68.8% and 25.9% of respondents suffered from depression, anxiety, and stress, respectively. Marital status was the only factor associated with stress among the respondents. The tested domains of QoL such as physical functioning, social functioning and emotional well-being showed a decrease in mean value when compared to Malaysian norm. It was observed that the QoL was afflicted with gender, marital status, and number of children. The study also proved that there are significant negative correlations between QoL with depression, anxiety, and stress. Conclusion: Reduced QoL among environmental health practitioners was associated with depression, anxiety, and stress during the COVID-19 pandemic. Government agencies or employers should impose an intervention programme, such as work rescheduling or a day off, to restore balance. © 2022 UPM Press. All rights reserved.